Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity
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چکیده
منابع مشابه
Methionine sulfoxide reductase regulates brain catechol-O-methyl transferase activity.
Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 2014
ISSN: 1461-1457,1469-5111
DOI: 10.1017/s1461145714000467